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The severity of AEs were being graded on an FDA-specified scale for healthful Grownup and adolescent volunteers.23 Vital indications included systolic and diastolic arterial blood pressures, pulse, and respiratory price. Very important signs were being obtained at screening baseline and ahead of and after Every single review drug administration in trial A. In trial B, baseline critical signs had been obtained once for each phase just before paroxetine administration after which after right after Just about every paroxetine and research drug administration. Critical signs were being attained in trials A and B at the end of each cure section and in advance of discharge.
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